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Journal Article

Citation

Han S, Nah S, Choi S, Lee YH. Signa Vitae 2021; 17(1): 200-204.

Copyright

(Copyright © 2021, Pharmamed Mado)

DOI

10.22514/sv.2020.16.0042

PMID

unavailable

Abstract

BACKGROUND: Delayed neurological sequelae (DNS) is a major problem in carbon monoxide (CO) intoxication. Many other studies have showed whether serum NSE of acute phase can predict DNS in CO poisoning. However, no study has examined NSE levels after development of DNS. Therefore, we report serum NSE levels after the onset of DNS. Case presentation: We described the NSE levels in two cases of DNS. The first was a 33-year-old woman who presented with concentration problems 39 days after CO exposure. The second was a 51-year-old woman who presented with gait disturbance and urinary incontinence 23 days after CO exposure. Brain magnetic resonance imaging (MRI) and NSE levels were obtained in both patients. Brain MRI confirmed brain injury and the diagnosis of DNS was made. The NSE levels of the two patients were 12.51 and 16.18 ng/mL, respectively.

CONCLUSION: Although the initial NSE elevated level may be useful in the prediction of carbon monoxide induced DNS, it may be decreased to normal reference range after the onset of DNS. © 2021 The Authors. Published by MRE Press.


Language: en

Keywords

Poisoning; suicide attempt; hospitalization; cognitive defect; vertigo; carbon monoxide; carbon monoxide intoxication; intensive care unit; nuclear magnetic resonance imaging; Carbon monoxide; confusion; carboxyhemoglobin; brain injury; computer assisted tomography; disorientation; prospective study; Brain injury; Glasgow coma scale; protein blood level; creatinine; creatinine blood level; leukocyte count; hyponatremia; ataxia; electroencephalography; protein expression; Complications; cerebrospinal fluid analysis; urea nitrogen blood level; neurological complication; neurologic examination; globus pallidus; Article; incontinence; Mini Mental State Examination; tendon reflex; prednisolone; lumbar puncture; thyroid function; mycophenolate mofetil; hyperbaric oxygen therapy; electrochemiluminescence; gait disturbance; neuron specific enolase; Neuron specific enolase

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