Citation

Majeed S, Shoaib MH, Ahmad FR, Mahmood K, Nisar N, Sohail K, Riaz R, Afzal A, Hanif M. Latin American Journal of Pharmacy 2021; 40(12): 2873-2882.

Copyright

(Copyright © 2021)

DOI

unavailable

PMID

unavailable

Abstract

Use of toxic concentration of para-phenylenediamines (PPD) for suicide has become a serious problem in all over the world, which can be reduced by preparing absorbable magnetic microspheres. The aim of present studies was to prepare three types of magnetic iron oxide (Fe3O4) adsorbents having chitosan (CTS), naturally occurring halloysite nanotubes (HNTs) and their combination by co-emulsion precipitation. Effect of different concentrations of CTS, HNTs and Fe3O4, their contact time with PPD, effect of different temperature and pH on adsorption were calculated. Magnetization was confirmed by vibrating sample manometer (VSM) which was ranged from 13.99 to 24.55 emu/g. Clear peaks of Fe and O was confirmed by energy dispersive X-ray spectroscopy (EDS). Interestingly, morphology of magnetic microspheres (FeHC7) was hollow spherical considered ideal for adsorption (1085.47 + 5.2 mg/g at 40 °C in pH 3.5) of PPD. Prepared FeHC7 microspheres can be considered as alternative approaches to reduce the complications of the gastric lavage in suicidal patients in emergency conditions. © 2021, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.

Language: en

Keywords

human; X ray diffraction; stomach lavage; pH; magnetic field; drug synthesis; drug formulation; Fourier transform infrared spectroscopy; surface property; Article; adsorption; temperature; structure analysis; emulsion; microsphere; physical chemistry; chitosan; concentration (parameter); adsorbent; contact time; elemental analysis; energy dispersive X ray spectroscopy; halloysite nanotube; halloysite nanotubes; magnetic microspheres; magnetite; para-phenylenediamines; thermogravimetry