Citation

Bertol E, Vaiano F, Argo A, Zerbo S, Trignano C, Protani S, Favretto D. Toxics (Basel) 2021; 9(12).

Copyright

(Copyright © 2021, MDPI: Multidisciplinary Digital Publishing Institute)

DOI

10.3390/toxics9120339

PMID

unavailable

Abstract

Quetiapine is an atypical antipsychotic drug used to treat bipolar disorder, schizophrenia, and major depressive disorder. Although several studies describe the adverse effects of intoxication with Quetiapine, only a few report an extreme overdose without comedications that lead to a life threat. We present a case of a 75-year-old male who tried to attempt suicide by ingesting 28 g of Quetiapine. During the management in the emergency department, both serum and urine samples were collected, allowing a complete pharmacokinetic analysis to be conducted, from the admission to the discharge. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Language: en

Keywords

Intoxication; human; male; aged; resuscitation; case report; bipolar disorder; depression; suicide attempt; drug overdose; clinical article; drug intoxication; hospital admission; clinical feature; quetiapine; stomach lavage; emergency ward; activated carbon; emergency health service; drug blood level; drug urine level; QT interval; hospital discharge; heart arrest; QT prolongation; drug absorption; electrocardiogram; Quetiapine; thorax pain; stomach content; Article; unconsciousness; drug detoxification; comatose patient; medical history; electrospray mass spectrometry; halazepam; maximum plasma concentration; pill; gastric suction; limit of quantitation; semicoma; liquid chromatography-mass spectrometry; urine sampling; multiple reaction monitoring; QT-prolongation; teva; triple quadrupole mass spectrometry