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Citation
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Davidouski S, Ibragimova Z, Goncharik, Kartun L, Chodosovskaya L, Leonov N, Semiarykhina S. Laboratory Diagnostics. Eastern Europe 2021; 10(2): 130-145. |
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Abstract
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Introduction. It has now been found that the violation of the stress response significantly increases the risk of suicide.
PURPOSE. To study the hormonal and metabolic status of persons, who have a suicide attempt.
MATERIALS AND METHODS. Two groups of suicidal risk were formed: persons who had suicidal attempt with high probability of death (GSAD); persons who had suicidal attempt in other ways (GSA). The comparison group (CG) included persons with the diagnosis of adjustment disorder. The content of the hormone cortisol, adrenocorticotropic hormone (ACTH), corticoliberin (CTRH), cholesterol (CH), low-density lipoprotein cholesterol (LDL-CH), and cholesterol of high density (HDL-CH) in peripheral blood was studied. The severity of the transferred psychosocial stress was assessed using the Holmes-Range Stress Scale, motivation to commit suicide - on a 10-point scale.
RESULTS. A statistically significant difference was found in the level of cortisol, CH, LDL-CH, the severity of stress, and motivation to commit suicide in patients of the study groups. In males of the suicidal risk groups, disorganization of the functional activity of the hypothalamic-pituitary-adrenal axis (HPA) was revealed.
CONCLUSIONS. The research groups differed in terms of cortisol, СН, LDL-CН, severity of stress, and motivation to commit suicide. The level of ACTH and CTRH in men tended to increase in the suicidal risk groups. In males of the suicidal risk groups, disorganization of the functional activity of HPA was revealed. For females of the suicidal risk groups on the background of the higher levels of CН and LDL-CН, there were no signs of disorganization of the HPA. The groups of suicidal risk are characterized by lower values of cholesterol regardless of gender. © 2021, Professionalnye Izdaniya. All rights reserved.
Language: ru |