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Abstract
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OBJECTIVE: To explore the correlation between the occurrence of violent behaviors and thyroid hormones in patient with mood disorders.
METHODS: The clinical data of 182 cases of mood disorders were collected to analyze the relationship of the serum levels of FT3, FT4, and TSH to the occurrence of violence behaviors.
RESULTS: There were differences in manic episodes (χ2=40.393, P< 0.001) and depressive episodes (χ2=13.549, P< 0.001), FT3 levels (Mann-Whitney U=2 022.0, P< 0.05) and FT4 levels (Mann-Whitney U=1 992.0, P< 0.05) between the group of violence and the group of non-violence. There were differences in serum FT3 levels (Mann-Whitney U=104.0, P< 0.05) and TSH levels (Mann-Whitney U=135.0, P< 0.05) between the violence group and the non-violence group in male patients, while the differences were found in serum FT4 levels in female patients (Mann-Whitney U=975.5, P< 0.05). There were differences in serum FT3 levels (Mann-Whitney U=1 138.0, P< 0.05) and FT4 levels (Mann-Whitney U=1 214.5, P< 0.05) between the group of violence and the group of non-violence in the non-suicide patients; There were differences in serum TSH levels (Mann-Whitney U=565.0, P< 0.05) between the group of violence and the group of non-violence in the group of mania; There were differences in serum FT4 levels (Mann-Whitney U=525.5, P< 0.05) between the group of violence and the group of non-violence in the group of depression; There were differences in serum FT3 levels(Mann-Whitney U=328.5, P< 0.05) between the group of violence and the group of non-violence in the group of non-depression; Manic episodes(OR=18.109, P< 0.001), FT3 (OR=3.036, P< 0.05) and FT4 (OR=13.436, P< 0.05) were risk factors for violence behaviors in patients with mood disorders; Depressive episodes were a protective factor for violent behaviors in patients with mood disorders (OR=0.260, P< 0.001); Manic episodes (OR=23.538, P< 0.05), FT3(OR=77.577, P< 0.05) and TSH (OR=77.577, P< 0.05) were risk factors for violent behaviors in patients with mood disorders in males; Manic episodes (OR=16.162, P< 0.001) and FT4 (OR=12.663, P< 0.05) were risk factors for violent behaviors in patients with mood disorders in females; Depressive episode was a protective factor for violent behaviors in patients with mood disorders in females(OR=0.206, P< 0.05); Multivariate binary logistic regression analysis showed that FT3 (OR=870 236.339, P< 0.05) was a risk factor for violence in males.
CONCLUSION: There were differences in serum thyroid hormone levels between the violence group and the non-violence group in patients with mood disorders; Elevated serum free thyroxin level was a risk factor for violent behavior in patients with mood disorders. FT3 was a risk factor for violent behavior in male patients. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.
Language: zh |