Citation

Chan WS, Wong GF, Lee WM. Forensic Sci. Int. Rep. 2021; 3.

Copyright

(Copyright © 2021, Elsevier Publishing)

DOI

10.1016/j.fsir.2021.100181

PMID

unavailable

Abstract

Carfentanil is a highly potent fentanyl analogue as well as a new psychoactive substance (NPS) which aroused concerns and research efforts in recent years. In this paper, 2 cases involving carfentanil and the quantitative assay using LC-MS/MS is described. Deceased 1 was a 52-year-old male with carfentanil detected in the peripheral blood at a level of 0.5 ng/mL. Carfentanil was also detected in the gastric content. Deceased 2 was a 25-year-old male with carfentanil detected in iliac blood at a level of 0.9 ng/mL. Without information revealing the potential involvement of carfentanil, screening of gastric content provided crucial information in these cases. Since the carfentanil concentration was very low in the blood, a sensitive LC-MS/MS method for determination of carfentanil in blood is also described. © 2021 The Authors

Language: en

Keywords

adult; human; Toxicology; female; male; Hong Kong; autopsy; suicide attempt; drug overdose; Post-mortem; LC-MS/MS; controlled study; validation process; coma; drug screening; pregabalin; montelukast; stomach content; toxicity testing; diclofenac; quantitative analysis; mass fragmentography; Article; Indian; tetrahydrolipstatin; young adult; meloxicam; prazepam; brotizolam; nalorphine; methaqualone; desloratadine; ofloxacin; limit of quantitation; measurement accuracy; measurement precision; carfentanil; Carfentanil; liquid chromatography-mass spectrometry; olopatadine; ornidazole