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Citation
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Xu M, Zhang M, Zhang Q, Zhang G, Liao J, Lei Z, Lan R, Yao S, Zhao Y, Chen Y. Zhongguo quanke yixue 2021; 24(29): 3742-3750. |
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Abstract
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BACKGROUND: The number of bariatric surgeries is increasing rapidly worldwide, which may significantly promote weight loss in obese patients, and help to improve diabetes, hypertension and other diseases, but may also increase the risk of suicide and other adverse events. Therefore, comprehensive and systematic studies are needed to assess the impact of bariatric surgery on multiple health-related outcomes.
OBJECTIVE: To examine the influence of bariatric surgery on various health-related outcomes other than weight loss.
METHODS: We searched databases of PubMed, Web of Science, EMBase, and The Cochrane Library from the inception to September 20, 2020, for systematic reviews/meta-analyses of the associations between bariatric surgery and health-related outcomes. Each study was screenedby two authors separately based on the inclusion and exclusion criteria. The 11-item AMSTAR was used for methodological quality assessment.
RESULTS: Twenty-five meta-analyses were included. The median AMSTAR score for the meta-analyses was 10(7, 11). Among the 54 outcomes in these meta-analyses, bariatric surgery was found to be associated with a lower risk of multiple cancers, and decreased cancer mortality, all-cause mortality, and cardiovascular mortality. Besides, bariatric surgery improved health quality and multiple chronic diseases, particularly type 2 diabetes, cardiovascular diseases, urinary incontinence, and nonalcoholic fatty liver disease. Several functional outcomes including sexual function, pulmonary function, renal function, and physical activity were also improved after bariatric surgery. However, bariatric surgery also increased the risk of suicide, self-harm, emotional eating, and adverse perinatal outcomes.
CONCLUSION: The majority of health-related outcomes are improved after bariatric surgery, but it should be cautious that bariatric surgery might increase the risk of adverse mental and perinatal problems. Because the methodological quality of some includ meta-analyses and the evidence quality of some health-related outcomes are comparatively low, more high-quality clinical studies and systematic reviews are still needed in the future. Copyright © 2021 by the Chinese General Practice.
Language: zh |