Citation

Al-Harbi SD, Mashi AH, AlJohani NJ. Clin. Med. Insights Case Rep. 2021; 14.

Copyright

(Copyright © 2021, Libertas Academica)

DOI

10.1177/11795476211027668

PMID

unavailable

Abstract

Cushing's disease is an abnormal secretion of ACTH from the pituitary that causes an increase in cortisol production from the adrenal glands. Resultant manifestations from this excess in cortisol include multiple metabolic as well as psychiatric disturbances which can lead to significant morbidity and mortality. In this report, 23-year-old woman presented to mental health facility with history of severe depression and suicidal ideations. During evaluation, she found to have Cushing's disease, which is unusual presentation. She had significant improvement in her symptoms with reduction of antidepressant medications after achieving eucortisolism. Cushing syndrome can present with wide range of neuropsychiatric manifestations including major depression. Although presentation with suicidal depression is unusual. Early diagnosis and prompt management of hypercortisolsim may aid in preventing or lessening of psychiatric symptoms The psychiatric and neurocognitive disorders improve after disease remission (the normalization of cortisol secretion), but some studies showed that these disorders can partially improve, persist, or exacerbate, even long-term after the resolution of hypercortisolism. The variable response of neuropsychiatric disorders after Cushing syndrome remission necessitate long term follow up. © The Author(s) 2021.

Language: en

Keywords

adult; human; female; case report; depression; suicide attempt; acne; mood disorder; clinical article; hydrocortisone; clinical feature; fluoxetine; headache; quetiapine; sleep disorder; follow up; hypercortisolism; menstrual irregularity; muscle weakness; hirsutism; Article; dyslipidemia; amenorrhea; impaired glucose tolerance; young adult; hypophysis adenoma; Cushing disease; sadness; body weight gain; cushing disease; cushing syndrome