Citation

Alvarado-Esquivel C, Estrada-Martínez S, Ramos-Nevárez A, Pérez-álamos AR, Beristain-García I, Alvarado-Félix O, Cerrillo-Soto SM, Sifuentes-álvarez A, Alvarado-Félix GA, Guido-Arreola CA, Saenz-Soto L. Pathogens (Basel) 2021; 10(6).

Copyright

(Copyright © 2021, MDPI: Multidisciplinary Digital Publications Institute)

DOI

10.3390/pathogens10060677

PMID

unavailable

Abstract

This study aimed to determine the association between suicidal behavior and T. gondii seroreactivity in 2045 patients attending primary care clinics. IgG antibodies against T. gondii were found in 37 (12.1%) out of 306 individuals with a history of suicidal ideation and in 134 (7.7%) of 1739 individuals without this history (OR: 1.64; 95% CI: 1.11-2.42; p = 0.01). Seropositivity to T. gondii was associated with suicidal ideation in women (OR: 1.56; 95% CI: 1.01-2.42; p = 0.03) and individuals aged ≤30 years (OR: 3.25; 95% CI: 1.53-6.88; p = 0.001). No association between the rates of high (>150 IU/mL) levels of anti-T. gondii IgG antibodies and suicidal ideation or suicide attempts was found. IgG antibodies against T. gondii were found in 22 of 185 (11.9%) individuals with a history of suicide attempts and in 149 (8.0%) of 1860 individuals without this history (OR: 1.54; 95% CI: 0.96-2.49; p = 0.06). The seroprevalence of T. gondii infection was associated with suicide attempts in individuals aged 31-50 years (OR: 2.01; 95% CI: 1.09-3.71; p = 0.02), and with more than three suicide attempts (OR: 4.02; 95% CI: 1.34-12.03; p = 0.008). Our results indicate that T. gondii exposure is associated with suicidal behavior among patients attending primary care clinics. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Language: en

Keywords

adult; human; Epidemiology; age; female; male; aged; Primary care; suicidal ideation; prevalence; Suicidal behavior; suicide attempt; interview; suicidal behavior; major clinical study; primary medical care; controlled study; questionnaire; disease association; middle aged; nonhuman; primary health care; cross-sectional study; Cross-sectional study; Article; enzyme linked immunosorbent assay; immunoglobulin G; immunoglobulin M; toxoplasmosis; Toxoplasma gondii; seroprevalence; antibody; Seroprevalence