Citation

Li X, Yu R, Huang Q, Chen X, Ai M, Zhou Y, Dai L, Qin X, Kuang L. Front. Hum. Neurosci. 2021; 15.

Copyright

(Copyright © 2021, Frontiers Research Foundation)

DOI

10.3389/fnhum.2021.762343

PMID

unavailable

Abstract

Major depressive disorder (MDD) is one of the most widespread mental disorders and can result in suicide. Suicidal ideation (SI) is strongly predictive of death by suicide, and electroconvulsive therapy (ECT) is effective for MDD, especially in patients with SI. In the present study, we aimed to determine differences in resting-state functional magnetic resonance imaging (rs-fMRI) in 14 adolescents aged 12-17 with MDD and SI at baseline and after ECT. All participants were administered the Hamilton Depression Scale (HAMD) and Beck Scale for Suicide Ideation (BSSI) and received rs-fMRI scans at baseline and after ECT. Following ECT, the amplitude of low frequency fluctuation (ALFF) and fractional ALFF (fALFF) significantly decreased in the right precentral gyrus, and the degree centrality (DC) decreased in the left triangular part of the inferior frontal gyrus and increased in the left hippocampus. There were significant negative correlations between the change of HAMD (ΔHAMD) and ALFF in the right precentral gyrus at baseline, and between the change of BSSI and the change of fALFF in the right precentral gyrus. The ΔHAMD was positively correlated with the DC value of the left hippocampus at baseline. We suggest that these brain regions may be indicators of response to ECT in adolescents with MDD and SI. Copyright © 2021 Li, Yu, Huang, Chen, Ai, Zhou, Dai, Qin and Kuang.

Language: en

Keywords

adolescent; human; child; female; male; image analysis; suicidal ideation; depression; functional magnetic resonance imaging; hippocampus; controlled study; clinical article; electroconvulsive therapy; brain function; psychological rating scale; treatment response; Article; clinical indicator; MDD; Beck Scale for Suicide Ideation; Hamilton Depression Rating Scale; primary motor cortex; amplitude of low-frequency fluctuation; inferior frontal gyrus; ALFF; degree centrality; degree of centrality; fractional amplitude of low-frequency fluctuation; resting-state fMRI