Citation

Aydin K, Cetinkaya A. Journal of Critical and Intensive Care 2020; 11(3): 1-6.

Copyright

(Copyright © 2020)

DOI

10.37678/dcybd.2020.2518

PMID

unavailable

Abstract

OBJECTIVE: Intoxication is a major public health concern worldwide. The aim of our study was to evaluate cases of intoxication in medical intensive care unit (ICU) in terms of demographics characteristics, complications, treatments employed, and mortality.

METHODS: This was a retrospective, single-center, observational, descriptive study. The sample included patients over 18 years of age who had been diagnosed with intoxication in the medical ICU between July 1, 2018, and June 30, 2019. Patients' demographic characteristics, laboratory values, Acute Physiology and Chronic Health Evaluation (APACHE) II scores, poisoning severity scores, Glasgow Coma Scale (GCS) scores, complications developed, and clinical courses were reviewed. The primary outcome was 28-day mortality.

RESULTS: Eighty three patients were enrolled in this study. By sex, 56.6% of the patients were female and 43.4% male. Toxic agent exposure was unintentional in 25.3% of patients but associated with attempted suicide in 74.7%. The causative agents were drugs (72.3%), mushroom (15.7%), methyl alcohol (8.4%), and pesticides (3.6%). Analgesics and anti-inflammatory agents were most common causative agents among intoxication cases. The 28-day mortality was 4.8%. In all non-survivors, cause of death was methyl alcohol intoxication.

CONCLUSION: Intoxication was most commonly observed in young, married women, most commonly caused by drugs, and most often associated with attempted suicide. © 2020 by Turkish Society of Medical and Surgical Intensive Care Medicine-Available online at.

Language: en

Keywords

adult; Intoxication; human; mental health; Mortality; female; male; Poisoning; alcohol; multiple organ failure; shock; liver failure; mushroom; cause of death; mortality; hemodialysis; methanol; suicide attempt; hospitalization; liver transplantation; intoxication; visual impairment; alcohol consumption; major clinical study; controlled study; analgesic agent; antidepressant agent; antiinfective agent; neuroleptic agent; retrospective study; smoking; length of stay; tachycardia; middle aged; intensive care unit; pesticide; paracetamol; medical society; health care personnel; demography; medical documentation; hypotension; acute kidney failure; heart rate; alanine aminotransferase; aspartate aminotransferase; creatine kinase; acetylcysteine; glucose; Glasgow coma scale; antidiabetic agent; hypoglycemia; insulin; sodium; creatinine; potassium; body temperature; charcoal; glucagon; Intensive care; lactate dehydrogenase; bradycardia; lactic acidosis; cardiovascular agent; 4 methylpyrazole; antiinflammatory agent; drug hypersensitivity; Article; observational study; hemoglobin; outcome assessment; descriptive research; medical record review; prothrombin time; blood pressure monitoring; leukocyte; APACHE; clinical evaluation; breathing rate; mean arterial pressure; hypertensive agent; arterial carbon dioxide tension; silymarin; chloride; poisoning severity score; Charlson Comorbidity Index; platelet count; invasive ventilation; medical intensive care unit; single center study