Citation

Park YM. Brain Sci. 2020; 10(6): 1-10.

Copyright

(Copyright © 2020, Switzerland Molecular Diversity Preservation International (MDPI) AG)

DOI

10.3390/brainsci10060370

PMID

unavailable

Abstract

Mood disorders often accompany circadian rhythm abnormalities. The serotonergic system (STS) is related to mood and circadian rhythm. This study aimed to test whether serotonergic neurotransmission, using the loudness dependence of auditory evoked potential (LDAEP), is associated with circadian preference in patients with major depressive disorder (MDD). Depression severity was assessed in 18-65‐year‐old outpatients (n = 48) using the Beck Depression Inventory scores and Hamilton Depression Rating Scale at baseline. Additionally, various scales, including the Korean version of the Composite Scale of Morningness (K‐CSM), Korean version of the Mood Disorder Questionnaire (K‐MDQ), and Korean version of the Childhood Trauma Questionnaire (K‐ CTQ), were used. LDAEP was also measured at baseline. The subjects were divided into three groups according to the circadian preference using total K‐CSM scores (morningness (n = 10) vs intermediate (n = 19) vs. eveningness (n = 19)) and two groups according to median based on each K‐CSM score, respectively (higher K‐CSM (n = 25) vs. lower K‐CSM (n = 23)). The bipolarity, suicidality, and age at onset differed among the three groups. Impulsivity, depression severity, suicidality, hopelessness, bipolarity, frequency of emotional abuse, and age at onset differed between the two group divisions. Thus, the STS might serve as the mediator between the circadian system and mood. © 2020 by the author. Licensee MDPI, Basel, Switzerland.

Language: en

Keywords

adult; human; Childhood trauma; sexual abuse; female; male; aged; bipolar disorder; sex difference; Major depressive disorder; major depression; clinical trial; disease severity; circadian rhythm; age distribution; neurotransmission; onset age; electroencephalography; Beck Depression Inventory; physical abuse; Circadian rhythm; Article; Barratt Impulsiveness Scale; Beck Hopelessness Scale; Hamilton Anxiety Scale; emotional abuse; Childhood Trauma Questionnaire; beck scale for suicide ideation; Mood Disorder Questionnaire; Hamilton Depression Rating Scale; behavior assessment; Eveningness; auditory evoked potential; Circadian preference; composite scale of morningness; Morningness