Citation

Rocha MV, Nery-Fernandes F, Baldaçara L, Jackowski AP, de Castro Quarantini L, Ladeia-Rocha G, de Araujo Neto C, De Oliveira IR, Caribé A, Miranda-Scippa A. Arch. Clin. Psychiatry (São Paulo) 2020; 47(6): 187-191.

Copyright

(Copyright © 2020, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da USP)

DOI

10.15761/0101-60830000000260

PMID

unavailable

Abstract

BACKGROUND: Patients with Bipolar Disorder (BD) have the highest lifetime risk for suicidal behavior (SB) compared to other psychiatric disorders. Neuroimaging research provides evidence of some structural and functional abnormalities in the brain of BD suicide attempters (SA), but interpretation of these findings may represent a number of features.

OBJECTIVE: The purpose of this study was to evaluate the volume of the prefrontal cortex in euthymic BD type I outpatients, with and without history of SA.

METHODS: 36 euthymic BD I outpatients (18 with and 18 without suicide attempt history) were underwent structural MRI and total and regional gray matter volumes were assessed and compared with 22 healthy controls (HC).

RESULTS: We did not found any differences in all areas between suicidal and non-suicidal BD I patients and BD patients as a group compared to HC as well.

DISCUSSION: our findings suggest that can be a different subgroups of patients in relation to prefrontal cortex volumes according to some clinical and socio-demographic caractheristics, such as number of previous episodes and continuous use of medical psychotropic drugs that may induce neuroplasticity phenomena, which restore cerebral volume and possibly can lead to long-term euthymia state. © 2020, UNIV SAOPAULO. All rights reserved.

Language: en

Keywords

human; Metaphor; head injury; Schizophrenia; white matter; schizophrenia; prefrontal cortex; suicide attempt; suicidal behavior; hospitalization; comorbidity; neuroimaging; mental disease; questionnaire; psychotropic agent; nuclear magnetic resonance imaging; demography; bipolar I disorder; brain size; caudate nucleus; Article; working memory; nerve cell plasticity; Young Mania Rating Scale; gray matter; image processing; Hamilton Depression Rating Scale; interpretation bias; neuroradiology; Pragmatic language