Citation

Al-Abdwani R. Oman Med. J. 2020; 35(4): 514-517.

Copyright

(Copyright © 2020, Oman Medical Specialty Board)

DOI

10.5001/OMJ.2020.104

PMID

unavailable

Abstract

Metformin is a widely used biguanide for the treatment of type 2 diabetes mellitus. Metformin-induced lactic acidosis (MALA) is a rare but potentially fatal entity in the pediatric age group, seen mainly in suicide attempts in adolescents. MALA has not yet been reported in younger patients or pediatric patients taking regular therapeutic doses. Here, we report a three-year-old female receiving therapeutic metformin who developed MALA. MALA should be suspected in patients with unexplained lactic acidosis and on regular metformin, especially in the setting of renal impairment or hypoxic events. © 2020, Oman Medical Specialty Board. All rights reserved.

Language: en

Keywords

Child, Preschool; human; child; female; case report; hospitalization; Metformin; clinical article; preschool child; noradrenalin; dopamine; drug withdrawal; acute kidney failure; propranolol; creatine kinase; glucose; creatinine; potassium; bradycardia; blood pressure; lactic acidosis; metformin; lactate blood level; urea nitrogen blood level; oxygen saturation; Article; hyperkalemia; drug dose increase; hyperlactatemia; breathing rate; biguanide; Acidosis, Lactic; blood pH; pediatric intensive care unit