Citation

Zhang R, Jiang X, Chang M, Wei S, Tang Y, Wang F. Ann. Gen. Psychiatry 2019; 18(1).

Copyright

(Copyright © 2019, Holtzbrinck Springer Nature Publishing Group - BMC)

DOI

10.1186/s12991-019-0243-5

PMID

unavailable

Abstract

OBJECTIVE: Although many studies have shown that the corpus callosum (CC) may play an important role in bipolar disorder (BD) and suicide, the pathophysiological mechanism of BD underlying suicidal behavior is still unclear. This study aimed to explore the relationship between the CC, and BD and suicidal ideation using diffusion tensor imaging (DTI).

METHOD: A total of 203 participants (47 BD patients with suicidal ideation, 59 with BD without suicidal ideation, and 97 healthy controls [HC]) underwent DTI scanning at a single site. We examined the white matter integrity of the CC in the three groups.

RESULTS: A comparison among groups showed that BD patients with suicidal ideation had significant lower fractional anisotropy (FA) values than those of BD without suicidal ideation and HCs in the body and genu of the CC, and FA values of BD without suicidal ideation were significantly lower than those of HCs. However, in the splenium of corpus callosum, no difference was found between BD without suicidal ideation and HCs.

CONCLUSIONS: Our findings add to the evidence suggesting that the CC plays a key role in BD with suicidal ideation, especially with respect to the role of the genu and body of the CC subserving emotion regulation. © 2019 The Author(s).

Language: en

Keywords

adolescent; adult; human; female; male; bipolar disorder; Bipolar disorder; suicidal ideation; Suicidal ideation; risk assessment; major clinical study; controlled study; disease association; clinical feature; brain function; brain region; Article; corpus callosum; diffusion tensor imaging; fractional anisotropy; Corpus callosum; Diffusion tensor imaging; white matter injury