Citation

Charfi N, Hajbi K, Maâlej-Bouali M, Omri S, Feki R, Zouari N, Zouari L, Ben Thabet J, Maalej M. NPG Neurologie - Psychiatrie - Geriatrie 2019; 19(110): 91-98.

Copyright

(Copyright © 2019)

DOI

10.1016/j.npg.2018.08.004

PMID

unavailable

Abstract

We aimed to assess subjective quality of life (Qol) among elderly patients with schizophrenia compared to younger adults, and to determine clinical and therapeutic factors that impact their Qol. This cross-sectional, comparative study was conducted on 77 patients with schizophrenia (Group A: n = 47, age ≤ 40 years, Group B: n = 30, age ≥ 60 years). Older schizophrenic patients had significantly more impaired QoL in the physical and psychological health domains. These domains were negatively correlated with number of relapses and scores on the positive and negative syndrome scale (PANSS), and they were significantly more impaired among older schizophrenic patients with depression. Depression and severity of schizophrenia in the elderly should be therapeutic targets to improve the Qol of these patients. © 2018 Elsevier Masson SAS; Notre objectif était d'évaluer la qualité de vie (Qdv) subjective chez des patients âgés atteints de schizophrénie comparativement à des patients adultes jeunes et de déterminer les facteurs cliniques et thérapeutiques ayant un impact sur leur Qdv. Cette étude transversale et comparative a porté sur 77 patients atteints de schizophrénie (groupe A : n = 47, âge ≤ 40 ans ; groupe B : n = 30, âge ≥ 60 ans). La Qdv était significativement plus altérée dans les domaines de santé physique et psychologique chez les patients âgés. Ces domaines étaient négativement corrélés au nombre de rechutes et aux scores de la Positive And Negative Syndrome Scale (PANSS) et ils étaient significativement plus altérés chez les patients âgés déprimés. La dépression et la sévérité de la schizophrénie vieillie devraient constituer des cibles thérapeutiques afin d'améliorer la Qdv chez de tels patients. © 2018 Elsevier Masson SAS

Language: en

Keywords

adult; human; social interaction; Depression; suicide; female; male; aged; World Health Organization; quality of life; aging; Schizophrenia; depression; schizophrenia; hospitalization; disease severity; Psychopathology; comparative study; major clinical study; middle aged; groups by age; family history; cross-sectional study; onset age; Quality of life; relapse; schizoaffective psychosis; Ageing; Article; Positive and Negative Syndrome Scale; Calgary Depression Scale