Citation

Prescrire Int. 2019; 28(206): 183-189.

Copyright

(Copyright © 2019, Association Mieux Prescrire)

DOI

unavailable

PMID

unavailable

Abstract

In addition to the fact that the efficacy of neuroleptics in treating the symptoms of psychotic episodes varies between patients, some of whom will already have tried these drugs, the main differences between the various neuroleptics lie in their adverse effects. Amisulpride, paliperidone and risperidone cause fewer extrapyramidal effects than haloperidol, and do not appear to cause substantially more metabolic adverse effects. Olanzapine, quetiapine and clozapine have less favourable harm-benefit balances than the other neuroleptics. Copyright © Prescrire.

Language: en

Keywords

human; suicide; Review; dementia; depression; psychosis; suicide attempt; clozapine; neuroleptic agent; sexual dysfunction; cognitive defect; sedation; neutropenia; quetiapine; orthostatic hypotension; haloperidol; sudden death; placebo; cardiomyopathy; extrapyramidal symptom; olanzapine; risperidone; agranulocytosis; hyperprolactinemia; mania; amisulpride; diabetes mellitus; positive syndrome; agitation; QT prolongation; impulse control disorder; aripiprazole; phenothiazine derivative; neuroleptic malignant syndrome; myocarditis; venous thromboembolism; skin disease; paliperidone; faintness; body weight gain; publication bias