Citation

Salarvan S, Sparding T, Clements C, Rydén E, Landén M. Int. J. Bipolar Disord. 2019; 7(1).

Copyright

(Copyright © 2019, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1186/s40345-019-0149-9

PMID

unavailable

Abstract

BACKGROUND: Comorbid attention-deficit/hyperactivity disorder (ADHD) is common in bipolar disorder and associated with worse outcomes. Cognitive testing might be a tool to identify this group. Here we compare the neuropsychological profiles of bipolar disorder patients with (BD + cADHD) and without (BD − cADHD) childhood attention-deficit hyperactivity disorder.

METHODS: Adult patients with BD − cADHD (n = 66), BD + cADHD (n = 32), and healthy controls (n = 112) were tested using a comprehensive battery of neuropsychological tests. Patients underwent rigorous diagnostic assessments for bipolar disorder and ADHD, as well as a parental interview to establish childhood ADHD.

RESULTS: The neuropsychological profiles of the groups were similar, except that the BD + cADHD group performed significantly worse on working memory. Working memory did not differ between those in the BD + cADHD group who only had a history of childhood ADHD and those that still met criteria for ADHD in adulthood.

CONCLUSIONS: Cognitive testing had limited power to differentiate between bipolar disorder adults with and without childhood ADHD. The BD + cADHD subgroup cannot explain the significant cognitive heterogeneity seen in bipolar disorder patients. © 2019, The Author(s).

Language: en

Keywords

adult; human; cognition; female; male; Comorbidity; decision making; bipolar disorder; Bipolar disorder; suicide attempt; interview; lithium; comorbidity; drug abuse; planning; substance abuse; major clinical study; controlled study; antidepressant agent; neuroleptic agent; self report; priority journal; intelligence; anamnesis; mania; neuropsychology; hypomania; attention deficit disorder; DSM-IV; neuropsychological test; Neuropsychology; intelligence quotient; central stimulant agent; Montgomery Asberg Depression Rating Scale; Article; working memory; Attention-deficit/hyperactivity disorder; Young Mania Rating Scale; verbal memory; Wender Utah Rating Scale; DSM-5; continuous performance test; Cognitive function; Wechsler adult intelligence scale; Delis-Kaplan executive function system; Mini International Neuropsychiatry Interview; Rey Osterrieth complex figure test; trail making test