Citation

Štros J, Polášek R, Seiner J, Karásek J. Cor Vasa 2019; 61(5): 529-533.

Copyright

(Copyright © 2019, Avicenum [etc.] Basel, distributed by Karger-Libri AG.)

DOI

10.1016/j.crvasa.2018.08.003

PMID

unavailable

Abstract

Yew intoxication is an uncommon, life-threatening emergency. Patients frequently die due to refractory cardiac shock or pulseless ventricular tachycardia and ventricular fibrillation, both of which do not respond to classical treatment with antiarrhythmics and defibrillation. The cardiac toxicity is driven mainly by taxine B, both sodium and calcium channel blocker. Hemodialysis is ineffective, because of the large molecular size of taxine B. Specific antidote is currently not available, but digoxin-specific FAB antibodies can be used instead, with partial effect. Severe cases of intoxication can profit from initiation of veno-arterial extracorporeal membrane circulation (VA ECMO). We present a case of a 25-year-old patient with yew and escitalopram ingestion in a suicide attempt. He presented to the emergency department of a regional hospital with cardiology center without cardiosurgery clinic, but with VA ECMO team on site. Pulseless ventricular tachycardia and fibrillation unresponsive to usual treatment developed soon after presentation and the patient had to be placed on VA ECMO during ongoing cardiopulmonary resuscitation using Lucas CPR device. The patient survived and was successfully weaned off VA ECMO after 4 days with normalization of cardiac function and without severe liver or kidney dysfunction. Unfortunately, brain death was diagnosed after the discontinuation of sedation two days later and the patient entered the transplantation program as a donor. This probably happened due to inadequate mechanical resuscitation during transportation to the cathlab. VA ECMO is an important option for the treatment of intoxications, with early indication being crucial. © 2019, ČKS

Language: cs

Keywords

adult; human; male; resuscitation; case report; suicide attempt; intoxication; clinical article; drug intoxication; sedation; brain death; escitalopram; heart ventricle tachycardia; Article; extracorporeal oxygenation; heart fibrillation; B VA ECMO; ECPR; Escitalopram intoxication; Taxine; veno arterial extracorporeal membrane circulation; yew intoxication; Yew intoxication