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Citation |
Ochi S, Inoue S, Yoshino Y, Shimizu H, Iga JI, Ueno SI. Clin. Psychopharmacol. Neurosci. 2019; 17(4): 559-563. |
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Copyright |
(Copyright © 2019, Korean College of Neuropsychopharmacology) |
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DOI |
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PMID |
unavailable |
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Abstract |
Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-refractory schizophrenia, and they are treated with clozapine. However, clozapine is sometimes combined with electroconvulsive therapy (ECT) if clozapine monotherapy fails. In this report, a severe treatment-refractory schizophrenic patient who did not respond to clozapine even with ECT, but who recovered with asenapine monotherapy, is presented. Asenapine, considered a serotonin spectrum dopamine modulator, is a new atypical antipsychotic with unique pharmacological features that is used not only for schizophrenia, but also for bipolar disorder. The unique features of asenapine may be effective for some treatment-refractory schizophrenic patients. © 2019, Korean College of Neuropsychopharmacology. Language: en |
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Keywords |
adult; human; Suicide; female; case report; depression; schizophrenia; psychosis; suicide attempt; clozapine; Electroconvulsive therapy; Clozapine; Recurrence; clinical article; hospital admission; psychiatric department; quetiapine; somnolence; electroconvulsive therapy; hostility; seizure; drug efficacy; extrapyramidal symptom; risperidone; hospital discharge; guilt; drug withdrawal; hyperprolactinemia; computer assisted tomography; outpatient department; eosinophilia; outpatient care; thinking; atypical antipsychotic agent; electroencephalography; iron deficiency anemia; auditory hallucination; drug dose reduction; Article; persecutory delusion; amenorrhea; blood examination; drug dose increase; medical history; clinical effectiveness; drug substitution; Positive and Negative Syndrome Scale; pelvis fracture; excitement; suspiciousness; asenapine; Global Assessment of Functioning; arm fracture; time to treatment; Asenapine; milk production; Treatment-refractory schizophrenia |