Citation

Hocagil H, İzci F, Hocagil AC, Tatli M, Sözen S, Akkaya Hocagil T. Turk. Klin. J. Med. Sci. 2019; 39(3): 237-244.

Copyright

(Copyright © 2019, Hekimler Birliği Vakfı)

DOI

10.5336/medsci.2018-64073

PMID

unavailable

Abstract

OBJECTIVE: Drug-induced rhabdomyolysis is the most common cause of disorders leading to acquired muscular inflammation. The aim of this study is to investigate rhabdomyolysis frequency in patients admitted to the emergency room (ER) due to one or different types of multiple drug ingestion with suicidal intentions. Material and Methods: This prospective clinical study was performed between June 2013 and November 2013 in Dr. Lütfi Kirdar Kartal Training and Research Hospital's ER, which had a daily admittance average of 800-1000 patients. The study included 103 patients. Creatinephosphokinase in the blood and myoglobin in the urine examined at the 3rd, 6th, 12th and 24th hours of admission to the ER.

RESULTS: Of the patients, 77 (74.8%) were female and 26 (25.2%) were male. Mean age was 28.8±9.5 years. Male subjects ingested a greater variety and a greater number of drugs than female subjects (p<0.05). Creatine phosphokinase level was found to be higher in the patients who took a higher number of drugs. Creatine phosphokinase was higher than 171 (U/L) in 15 patients (14.6%). Myoglobinuria was detected in 7.8% of all patients. No rhabdomyolysis was observed in patients who were admitted to the hospital within the first 3 hours of ingestion. The most commonly used agent for suicide attempt was non-steroidal antiinflammatory drugs (NSAIDs) (36.9%), paracetamol (31.1%) and antidepressants (30.1%).

CONCLUSION: It was found that patients with delayed admission to the ER had a higher incidence of rhabdomyolysis. Antidepressants were the third leading agents used for suicidal intentions following NSAIDs and paracetamol. © 2019 by Türkiye Klinikleri.

Language: en

Keywords

adult; human; female; male; Suicide attempt; suicide attempt; drug overdose; rhabdomyolysis; alcohol consumption; major clinical study; antidepressant agent; informed consent; drug induced disease; middle aged; stomach lavage; emergency ward; acetylsalicylic acid; paracetamol; nonsteroid antiinflammatory agent; naproxen; prospective study; creatine kinase; blood; histamine H2 receptor antagonist; muscle relaxant agent; ibuprofen; myoglobinuria; diclofenac; Article; cardiac agent; Rhabdomyolysis; myoglobin; etodolac; ketoprofen; oral antidiabetic agent