Citation

Akhgari M, Kahfi MS, Akha AHS. Indian J. Pharm. Sci. 2019; 81(1): 32-38.

Copyright

(Copyright © 2019, Medknow Publications)

DOI

10.4172/pharmaceutical-sciences.1000476

PMID

unavailable

Abstract

The aim of the present study was to provide an overview of deaths caused by drug poisoning or intoxication with other substances in Qom province, Iran from 2008 to 2012. The data on poisoning deaths were collected from the autopsy reports and defined cause of death in death certificates. Death profiles and demographic characteristics were analysed. Intoxication death cases were recorded 388 subjects during the five year study period, of which 264 cases (68 %) were male.

RESULTS showed that the rate of intoxication deaths was 93 cases per one million populations in 2008, decreasing to 49 cases in 2010 and then increasing to 69 cases in 2012. Opium alkaloids caused the highest mortality rate in male and female cases. Tramadol and tricyclic antidepressants were the second cause of death in males and females, respectively. The majority of cases were in the age range of 21-30 years. Accidental poisoning with opioids was the most reported manner of death. Death cause analysis revealed that opioids contributed to death in the majority of cases. The findings of the present study highlight the importance of regulatory controls on clandestine illicit opioid production, distribution and abuse by heath care authorities. © 2019 OMICS International. All Rights Reserved.

Language: en

Keywords

adult; human; suicide; female; male; Iran; incidence; autopsy; prevalence; sex difference; cause of death; alcohol intoxication; substance abuse; Forensic toxicology; major clinical study; antidepressant agent; retrospective study; drug intoxication; high performance liquid chromatography; mass spectrometry; amitriptyline; tricyclic antidepressant agent; carbon monoxide; carbon monoxide intoxication; exhaust gas; opiate; carboxyhemoglobin; methamphetamine; tramadol; gas chromatography; methadone; illicit drug; cyanide; lidocaine; analytic method; thin layer chromatography; propranolol; opiate addiction; Toxicity; organophosphorus compound; liquid liquid extraction; pethidine; Article; mortality rate; potentiometry; flame ionization detection; Intoxication deaths; Opioid abuse; polarography