Citation

Kumar S, Thakur D, Gupta RK, Sharma A. Journal of Cardiovascular and Thoracic Research 2018; 10(4): 246-247.

Copyright

(Copyright © 2018)

DOI

10.15171/jcvtr.2018.43

PMID

unavailable

Abstract

Amlodipine is a dihydropyridine calcium channel blocker which is widely used as an anti-hypertensive drug. Amlodipine overdose have been infrequently reported with occurrence of serious complications and even death in a few cases. We report an interesting case of a young lady who presented with refractory shock with acute kidney injury, which did not respond to therapy despite optimal fluid replacement and vasopressor support. The etiology of shock could not be ascertained and the patient was questioned again to elucidate the missing clue in the history. It was finally revealed that the patient had consumed 900 mg of amlodipine in a suicide bid, for her poor performance in academics. The targeted therapy in the form of IV calcium and hyperinsulinemia-euglycemia therapy (HIET) was started and the patient dramatically improved with shock reversal and improvement in renal function. © 2018 The Author (s).

Language: en

Keywords

adult; human; female; shock; case report; suicide attempt; drug overdose; vomiting; clinical article; noradrenalin; dopamine; follow up; acute kidney failure; antibiotic agent; glucose; electrocardiogram; creatinine; creatinine blood level; respiratory failure; gluconate calcium; dyspnea; Amlodipine; thorax radiography; sinus tachycardia; treatment response; oxygen saturation; drug dose reduction; hyperinsulinemia; Article; tachypnea; Shock; arterial gas; continuous infusion; amlodipine; urine volume; ascites; oxygen breathing; young adult; pleura effusion; Vasopressor; foot edema; pig insulin; academic underachievement; HIET