Citation

Yu ZR, Du GH. Yao Xue Xue Bao 2018; 53(10): 1583-1590.

Copyright

(Copyright © 2018, Zhongguo yao xue hui)

DOI

10.16438/J.0513-4870.2018-0322

PMID

unavailable

Abstract

Depression is currently the most popular disease in the world with a high suicide rate. Selective 5-HT reuptake inhibitors have been used as first-line drugs in clinics, but the therapeutic effect is greatly limited. The pathogenesis of depression is complicated, meanwhile the cholinergic hypothesis has received more and more attention. A large number of clinical and preclinical studies have shown that antagonists and partial agonists acting on nicotinic acetylcholine receptors have a significant effect on antidepressant therapy, which can improve the hippocampus recognizes, influence rewards and anxiety systems controlled by the ventral midbrain and ventral tegmental area, and regulate the amygdala pressure system, thereby improving mood and relieving depression. At present, the relationship between the cholinergic system and depression is still undergoing a lot of research. In this article, the relationship between α4β2 nicotinic acetylcholine receptor (nAChRs) and depression is reviewed to provide a reference for study of new anti-depression drugs. © 2018 Zhonghua Yixuehui Zazhishe. All rights reserved.

Language: zh

Keywords

Depression; suicide; Review; depression; anxiety; hippocampus; Affective disorder; serotonin; unclassified drug; reward; therapy effect; nicotinic receptor; ventral tegmentum; cholinergic receptor; antidepressant activity; amygdala; alpha4beta2 acetylcholine receptor; Cholinergic hypothesis; ventral mesencephalon; α4β2 nicotinic acetylcholine receptor