Citation

Lixin Z, Dongyue G, Shuang L, Xiaoya L, Yue S, Dong M. Chinese Journal of Biomedical Engineering 2018; 37(5): 616-624.

Copyright

(Copyright © 2018)

DOI

10.3969/j.issn.0258-8021.2018.05.013

PMID

unavailable

Abstract

Depressive disorder is a mental disorder with significant and persistent depressed mood as its main clinical feature. It has become a serious public health problem due to high prevalence rate, high recurrence rate, high suicide rate and high disability rate. In addition to the commonly used methods of medicine, psychology and physics for the treatment of depression, the transcranial direct current stimulation (tDCS), which developed in recent years, has been widely concerned in physical therapy because of its advantages of convenient use, fewer side effects, no need for anesthesia and economy. As a non-invasive brain stimulation technology, tDCS can stimulate the prefrontal cortex to regulate the excitability of the cerebral cortex through the skull, thus achieving the goal of improving depressive symptoms. To date, many research using tDCS in the treatment of depression have confirmed that tDCS has significant antidepressant efficacy and can improve the cognitive status of depressed patients. It has become a promising new treatment of depression. This paper reviewed the application and research progress of tDCS in the treatment of depression from the therapeutic mechanism, efficacy, safety operation, problems, and future development. © 2018 Chinese Academy of Medical Sciences. All rights reserved.

Language: zh

Keywords

human; Review; Depressive disorder; depression; prefrontal cortex; antidepressant agent; drug safety; drug efficacy; Efficacy; brain cortex; transcranial direct current stimulation; Transcranial direct current stimulation (tDCS); Cognitive psychology; Therapeutic mechanism