Citation

Semančíková E, Tkáčiková S, Talian I, Bobrov N, Iannaccone SF, Šimonová J, Firment J, Dubinská S, Pálová E. Psychiatr. 2018; 22(2): 54-59.

Copyright

(Copyright © 2018, Tigis S R O)

DOI

unavailable

PMID

unavailable

Abstract

Despite the fact that proteomic analysis is becoming widely used in various medical fields its use in psychiatry is still very limited. We decided to study suicidal behaviour via cerebrospinal fluid and platelets with the use of proteomics. We identified a group of altered proteins in suicidal patients in the metabolic pathways of glycolysis/gluconeogenesis, complement and coagulation cascade and 14-3-3 mediated signaling pathway. Based on these findings we suppose that alterations of glucose metabolism (especially utilisation of glucose and altered response to oxidative stress) together with alterations in complement and coagulation cascade and 14-3-3 mediated signaling pathway may play a role in the neurobiology of suicide. However, further research is needed to clarify whether the identified group of proteins can be used as a potential peripheral biomarker for suicidal behaviour. © 2018 TIGIS Spol. s.r.o. All rights reserved.

Language: cs

Keywords

human; Suicide; pilot study; suicidal behavior; pathogenesis; Cerebrospinal fluid; signal transduction; metabolism; glucose metabolism; Article; biological marker; Platelets; cerebrospinal fluid; thrombocyte; proteomics; blood clotting; glycolysis; complement classical pathway; glucogenesis; protein 14 3 3; Proteomics