Citation

Rawat S, Kaur G, Yadav S, Khan MA, Kallur Nava S. Meta Gene 2018; 15: 84-86.

Copyright

(Copyright © 2018)

DOI

10.1016/j.mgene.2017.12.004

PMID

unavailable

Abstract

The present study aims to investigate the role of Global DNA Methylation in Depression. A total of 368 individuals (118 males and 250 females) were screened for depression using PHQ9 (Patient Health Questionnaire 9) and 5-mc% (5-methyl cytosine) content of Peripheral Leucocytes DNA was measured by enzyme linked calorimetric based MethyFlash™ methylated DNA quantification kit. Among individuals with depression a lower Global DNA methylation (though not significant) in terms of 5-mc% (5-methyl cytosine) content was observed compared to individuals without depression. © 2017

Language: en

Keywords

adult; human; Depression; female; male; aged; suicidal ideation; depression; Suicide ideation; alcohol consumption; major clinical study; priority journal; Alzheimer disease; chi square test; Article; rank sum test; Cronbach alpha coefficient; leukocyte; DNA methylation; patient health questionnaire; genome-wide association study; Global DNA hypomethylation