Citation

Guang-Fen Z, Jian-Jun Y. Chinese Pharmacological Bulletin 2018; 34(1): 1-4.

Copyright

(Copyright © 2018)

DOI

10.3969/j.issn.1001-1978.2018.01.001

PMID

unavailable

Abstract

Recent studies have demonstrated that ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, can produce rapid and effective antidepressant actions, especially for patients with treatment-resistant depression, bipolar disorder and suicide idea. However, the clinical application of ketamine is limited by its psychotomimetic adverse reactions and potential a-buse. Therefore, development of novel ketamine-like antidepressant agents with fewer side effects is actively investigated cur-rently. The latest researches indicate that the metabolites of ket-amine, the S-ketamine/R-ketamine and the modulators of NMDA receptor subunits can exert safe and effective antidepressant actions. In this article, the research advance in NMDA recep-tors-related antidepressants mentioned above will be reviewed. © 2018 Publication Centre of Anhui Medical University. All rights reserved.

Language: zh

Keywords

Ketamine; Antidepressant; Isoforms; Isomeride; Metabo-Lites; N-Methyl-D-Aspartate Receptor