Citation

Zhong QP, Xu JP. Journal of International Pharmaceutical Research 2016; 43(6): 1031-1036.

Copyright

(Copyright © 2016)

DOI

10.13220/j.cnki.jipr.2016.06.002

PMID

unavailable

Abstract

Depression is a common mental disorder, characterized by long-lasting sadness, loss of interest and desperation. People with depressive disorder have a high suicide risk, so depression has become a serious threat to an individual's health and life. Currently, development of anti-depressants is largely limited due to the complexity of this disorder. Clinically available antidepressants are still unable to meet the needs of patients because of both low efficacy and side effects. Recently, with the in-depth study, substantial evidence reveals that abnormalities in synaptic plasticity play important roles during the process of depression. Improving synaptic plasticity will be beneficial to ameliorating depressive symptoms and the accompanying cognitive dysfunction. Here, we review the role of synaptic plasticity during the development of depression and its association with brain-derived neurotrophic factor, astrocytes and microglia. © 2016, Editorial office of Journal of International Pharmaceutical Research. All rights reserved.

Language: zh

Keywords

human; Depression; suicide; Review; Microglia; risk factor; antidepressant agent; cognitive defect; brain derived neurotrophic factor; astrocyte; nerve cell plasticity; Brain-derived neurotrophic factor (BDNF); Astrocytes; Synaptic plasticity