Citation

Wagner JL, Wilson DA, Smith G, Malek A, Selassie AW. Dev. Med. Child Neurol. 2015; 57(1): 45-52.

Copyright

(Copyright © 2015, Mac Keith Press, Publisher John Wiley and Sons)

DOI

10.1111/dmcn.12555

PMID

unavailable

Abstract

AIM: To determine the distribution and risk characteristics of comorbid neurodevelopmental and mental health comorbidities among children and adolescents (6-18y) with epilepsy or migraine (i.e. a neurological condition with shared features and potential etiology) compared with lower extremity fracture (LEF).

METHOD: This case-control study involved a subset analysis of surveillance data in South Carolina, USA. Hospital admission, outpatient, and emergency department visits for individuals with an International Classification of Disease, 9th revision Clinical Modification diagnosis of epilepsy (n=6730; 54.5% females, 45.5% males; mean age [SD] 14y 2mo [4y 5mo]); migraine (n=10 495; 74.5% females, 25.5% males; 15y 6mo [2y 6mo]), or LEF (n=15 305; 40.3% females, 59.7% males; 13y 11mo [2y 11mo]) from January 1 2000 to December 31 2011 were identified. The association of epilepsy, migraine, or LEF with any mental health comorbidity was evaluated with univariate and multivariate polytomous logistic regression.

RESULTS: Comorbidities were highly prevalent in children and adolescents, with epilepsy with a rate of 29.7% (95% confidence interval [CI]: 28.6-30.8) for mental health comorbidities and 30.8% (95% CI: 29.7-31.9) for neurodevelopmental comorbidities. The odds of mental health comorbidity was 2.20 (95% CI: 2.02-2.39) for children and adolescents with epilepsy and 1.60 (95% CI: 1.48-1.73) for migraine, in reference to children and adolescents with LEF after adjusting for potential confounders. Prevalence and risk for specific comorbidities are presented.

INTERPRETATION: Neuropathophysiological and psychosocial factors specific to epilepsy may provide more risk for adolescents with epilepsy compared to migraine. © 2014 Mac Keith Press.

Language: en

Keywords

Humans; United States; adolescent; Child; Female; Male; human; Adolescent; mental health; child; female; male; Epilepsy; Comorbidity; Prevalence; bipolar disorder; suicidal ideation; depression; prevalence; schizophrenia; Case-Control Studies; suicide attempt; comorbidity; adolescent health; child health; epilepsy; migraine; comparative study; major clinical study; controlled study; personality disorder; cognitive defect; priority journal; childhood disease; health insurance; Mental Disorders; drug misuse; attention deficit disorder; case control study; adolescent disease; heart atrium septum defect; intellectual impairment; Article; South Carolina; hospital based case control study; Leg Injuries; Developmental Disabilities; Migraine Disorders; Fractures, Bone; nerve cell differentiation; social determinants of health; ICD-9-CM