Citation

Srinivasan G, Wyawahare M, Mathen PG, Subrahmanyam DK. J. Pharmacol. Pharmacother. 2015; 6(3): 179-181.

Copyright

(Copyright © 2015, Medknow Publications)

DOI

10.4103/0976-500X.162017

PMID

unavailable

Abstract

We report a case of a 41-year-old lady, who developed severe hypotension and sinus bradycardia, following oral consumption of 20 g of phenytoin and 500 mg of glibenclamide. She required high dose of inotropes and a temporary transvenous pacer for her hemodynamic instability. This life-threatening cardiotoxicity of phenytoin could have been due to its interaction with sulphonylurea. It is imperative to be aware of drug interactions, due to which, life-threatening cardiovascular manifestations following phenytoin toxicity can occur.

Language: en

Keywords

adult; human; female; case report; suicide attempt; disease severity; drug overdose; clinical feature; noradrenalin; dopamine; drug blood level; hypotension; drug megadose; drug effect; phenytoin; dose response; glibenclamide; electrocardiography; Cardiotoxicity; inotropic agent; stupor; Article; sinus bradycardia; pulse rate; sinus rhythm; life threat; sulphonylurea