Citation

Namera A, Konuma K, Kawamura M, Saito T, Nakamoto A, Yahata M, Ohta S, Miyazaki S, Shiraishi H, Nagao M. Forensic Toxicol. 2014; 32(1): 68-74.

Copyright

(Copyright © 2014, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s11419-013-0203-8

PMID

unavailable

Abstract

We report the time-course profile of urinary excretion of α-pyrrolidinovalerophenone (α-PVP) and α- pyrrolidinobutiophenone (α-PBP) after intravenous injection in a human. The subject was a man aged in his forties, who intravenously injected unknown amounts of so-called unregulated drugs with the intention to commit suicide. The urinary concentrations of the drugs were analyzed by MonoSpin® extraction and gas chromatography-mass spectrometry. α-PVP, α-PBP, and their 2′-oxo metabolites of these compounds were identified in the urine. The highest concentration of α-PVP and α-PBP in urine was 1.2 and 1.6 μg/ml, respectively. The excretion half-lives of α-PVP and α-PBP were calculated to be 22 and 11 h, respectively. To our knowledge, this is the first report on the urinary excretion profiles of α-PVP and α-PBP in a human. © 2013 Japanese Association of Forensic Toxicology and Springer Japan.

Language: en

Keywords

Human; GC-MS; Excretion half-life; Urine analysis; α-PBP; α-PVP