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Citation |
Agarwala R, Ahmed SZ, Wiegand TJ. J. Med. Toxicol. 2014; 10(2): 210-214. |
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Copyright |
(Copyright © 2014, Holtzbrinck Springer Nature Publishing Group) |
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DOI |
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PMID |
unavailable |
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Abstract |
INTRODUCTION: Intravenous lipid emulsion (ILE) resuscitation is now frequently being used for severe overdoses due to lipophilic drugs. However, the optimal dose, duration, and safety are still unclear. Case Report: A patient with refractory cardiovascular collapse following an amitriptyline overdose was treated with ILE with initial improvement. Instability recurred after ILE discontinuation and lipid therapy was restarted, but high-dose treatment was complicated by severe lipemia. A low-dose infusion was instead used, and the patient did not experience further toxicity despite amitriptyline levels in the toxic range for 21 days. He survived to discharge without long-term sequelae. Language: en |
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Keywords |
Humans; Adult; Male; adult; human; Severity of Illness Index; male; Poisoning; Drug Overdose; shock; Time Factors; Treatment Outcome; Suicide, Attempted; case report; Antidepressive agents; Antidotes; drug use; suicide attempt; treatment outcome; drug overdose; Recurrence; Combined Modality Therapy; article; amitriptyline; pathophysiology; tricyclic antidepressant agent; recurrent disease; noradrenalin; dopamine; tonic clonic seizure; hyperlipidemia; adrenalin; bicarbonate; heart ventricle fibrillation; time; low drug dose; electrocardiography; multimodality cancer therapy; Amitriptyline; Antidepressive Agents, Tricyclic; QRS complex; Shock; chemistry; arterial pH; warming; hypertensive agent; lipid emulsion; severity of illness index; Fat Emulsions, Intravenous; intralipid; electric activity; chemical phenomena; continuous renal replacement therapy; Fat emulsions; Hydrophobic and Hydrophilic Interactions; Hyperlipidemias; Intravenous; Tricyclic |