Citation

Gökbayrak NS, Piryatinsky I, Gavett RA, Ahmed OJ. Front. Neurol. 2014; 5 AUG.

Copyright

(Copyright © 2014, Frontiers Research Foundation)

DOI

10.3389/fneur.2014.00154

PMID

unavailable

Abstract

Although ̃50% of patients with Parkinson's disease (PD) experience depression, treatment for this important and debilitating comorbidity is relatively understudied. Deep brain stimulation (DBS) has been increasingly utilized for the management of tremors in progressive PD. Several preliminary studies have shown the potential benefit of DBS for non-motor PD symptoms such as depression. Here, we critically evaluate seven recent randomized clinical trials of the effectiveness of DBS in reducing depressive symptomatology among individuals with PD.

FINDINGS are mixed for the effectiveness of DBS as a treatment for depression in PD. Our review suggests that this is due, in large part, to the anatomical and methodological variation across the DBS studies. We provide a comprehensive discussion of these variations and highlight the need to conduct larger, more controlled studies aimed specifically at evaluating the treatment of depression in PD patients. © 2014 Gökbayrak, Piryatinsky, Gavett and Ahmed.

Language: en

Keywords

human; Depression; suicide; insomnia; depression; aggression; anxiety; scoring system; review; controlled study; self report; paranoia; irritability; Parkinson disease; obsessive compulsive disorder; brain region; treatment response; brain depth stimulation; globus pallidus; Parkinson's disease; subthalamic nucleus; clinical effectiveness; Deep brain stimulation; randomized controlled trial (topic); adverse outcome; DBS; Randomized clinical trial