Citation

Šóš P. Psychiatr. 2014; 18(4): 193-205.

Copyright

(Copyright © 2014, Tigis S R O)

DOI

unavailable

PMID

unavailable

Abstract

This literature review begins with a rationale for the development of new therapeutic approaches for the treatment of depressive disorder. In the following sections the history of the finding of ketamine's antidepressant effect, its pharmacological properties and application routes are summarized. The following is an overview of the existing scientific evidence of ketamine's efficacy in patients with unipolar and bipolar depression, suicidality and the adjuvant use in electroconvulsive therapy. Finally, the author discusses acute and chronic side effects, safety of repeated administration of ketamine and possibilities of extending the antidepressant effect. The last section summarizes recent findings on the mechanism of the antidepressant effect of ketamine on the molecular level and its effect on neuronal plasticity. © 2014, TIGIS Spol. s.r.o. All rights reserved.

Language: cs

Keywords

human; suicide; Review; Depressive disorder; ketamine; depression; major depression; BDNF; bipolar depression; Ketamine; drug mechanism; electroconvulsive therapy; drug safety; drug efficacy; unspecified side effect; adjuvant therapy; nerve cell plasticity; repeated drug dose; mTOR; antidepressant activity; Synaptogenesis