Citation

Shetye J, Surkar S, Karnik N, Mehta A. Indian J. Crit. Care Med. 2014; 18(2): 102-104.

Copyright

(Copyright © 2014, Indian Society of Critical Care Medicine, Publisher Medknow Publications)

DOI

10.4103/0972-5229.126082

PMID

unavailable

Abstract

Organophosphorus poisoning is a major global cause of health problems and the leading cause of mortality and morbidity in the developing countries. In this, the inhibition of acetyl-choline esterase and neurotoxic esterase along with nicotinic receptor involvement produces three well-identified and documented clinical phases: The initial cholinergic phase, which is a medical emergency often requiring management in an intensive care unit; the intermediate syndrome, during which prolonged ventilator care is necessary; and finally delayed neurotoxicity. Vocal cord paralysis is rare and leads to aphonia. Role of physiotherapy rehabilitation is substantial in all three stages and aims at early weaning off from mechanical ventilator until the functional independence and community integration of the patient.

Language: en

Keywords

adult; human; organophosphate; female; case report; suicide attempt; acetylcholinesterase; article; hospital admission; intensive care unit; enzyme inhibition; physiotherapy; bronchoscopy; vocal cord paralysis; neuropathy; trachea stenosis; tracheostomy; peroneus nerve paralysis; breathing exercise; spasticity; young adult; organophosphate poisoning; stridor; piperacillin plus tazobactam; lobar pneumonia; intermittent mandatory ventilation; nicotinic receptor; acute motor axonal neuropathy; hand malformation; aphonia; claw hand deformity; community integration; copious purulent secretion; delayed neurotoxicity; delayed onset neuropathy; mechanical ventilator; neurotoxic esterase; Organophosphate induced delayed neurotoxicity; recurrent laryngeal nerve palsy; recurrent laryngeal palsy; suppuration