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Citation |
Filler G, Ferrand A. Expert Opin. Drug Saf. 2014; 13(5): 521-524. |
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Copyright |
(Copyright © 2014, Informa Healthcare) |
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DOI |
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PMID |
unavailable |
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Abstract |
INTRODUCTION: To discuss the significance of the recent observational case series from the Swiss Toxicological Information Centre (STIC). Mycophenolic acid (MPA) and its prodrug mycophenolate mofetil are immunosuppressive agents that are frequently prescribed in renal transplant recipients, and their safety profiles must be established. Areas covered: This case series and systemic literature analysis consists of 15 cases of MPA overdose from the STIC and a systemic analysis of the literature over the past 18 years. This study focuses on acute overdosing, the effects of which are presumably mild. In contrast, the effects of long-term overdosing may be much more severe. Substantial underreporting is likely. The pharmacokinetic monitoring of MPA is rarely performed, which is both striking and does not coincide with findings in academic literature. The scant data on pharmacokinetic monitoring presented demonstrated that MPA has a short terminal half-life, which suggests that decontamination and activated charcoal treatment in acute overdose may not be necessary. Expert opinion: The case series and systematic literature analysis of acute mycophenolate overdose represent an important contribution toward increasing the safety of MPA therapy. © 2014 Informa UK, Ltd. Language: en |
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Keywords |
Humans; Female; Male; human; systematic review; female; male; Drug Overdose; Overdose; suicide attempt; drug overdose; review; drug intoxication; drug safety; food and drug administration; neurologic disease; drug monitoring; drug formulation; immunosuppressive treatment; immunosuppressive agent; kidney function; kidney graft rejection; kidney transplantation; mycophenolic acid 2 morpholinoethyl ester; home accident; Immunosuppressive Agents; virus reactivation; Mycophenolate mofetil; mycophenolic acid; Mycophenolic Acid; analogs and derivatives; Human toxicity; Mycophenolate sodium; Mycophenolic acid |