Citation

Zetterberg H, Jakobsson J, Redsäter M, Andreasson U, Pålsson E, Ekman CJ, Sellgren C, Johansson AGM, Blennow K, Landén M. Psychiatry Res. 2014; 217(3): 143-146.

Copyright

(Copyright © 2014, Elsevier Publishing)

DOI

10.1016/j.psychres.2014.03.045

PMID

unavailable

Abstract

Blood-cerebrospinal barrier (BCB) dysfunction has previously been shown in subjects with schizophrenia and depressed patients with attempted suicide. Bipolar disorder (BPD) shares clinical features with both these disorders, but it is unknown if the integrity of the BCB is altered also in BPD. To assess if BCB function in BPD we surveyed 134 mood-stabilized BPD patients and 86 healthy controls. Serum and cerebrospinal fluid (CSF) samples were collected and analyzed for albumin concentration by immunonephelometry. CSF/serum albumin ratio, an established measure of BCB function, was significantly elevated in BPD patients as compared to controls. After stratifying patients according to diagnostic subtype, BPD I patients had the highest CSF/serum albumin ratios. Moreover, BPD patients on antipsychotic treatment had higher CSF/serum albumin ratio than BPD patients on other treatments. When excluding BPD patients on antipsychotic treatment the difference in CSF/serum albumin ratio between the BPD and control groups disappeared. In conclusion, antipsychotic treatment in BPD is associated with elevated CSF/serum albumin ratio, tentatively as a sign of impaired BCB function. Whether this elevation is caused by antipsychotic treatment or is associated with a certain subtype of BPD, requiring antipsychotic treatment, remains to be determined. © 2014 Elsevier Ireland Ltd.

Language: en

Keywords

Humans; Adult; Female; Male; Middle Aged; adult; human; female; male; bipolar disorder; Bipolar disorder; lithium; psychology; Cerebrospinal fluid; article; major clinical study; controlled study; anticonvulsive agent; antidepressant agent; anxiolytic agent; disease association; neuroleptic agent; blood sampling; pathophysiology; priority journal; middle aged; albumin; albumin blood level; Bipolar Disorder; neurologic disease; blood; cerebrospinal fluid analysis; Antipsychotic Agents; cerebrospinal fluid; blood brain barrier; protein cerebrospinal fluid level; Serum Albumin; Blood-Brain Barrier; serum albumin; drug effects; Albumin ratio; blood cerebrospinal fluid barrier; blood cerebrospinal fluid barrier dysfunction; Blood-cerebrospinal fluid barrier function; immunonephelometry; nephelometry