Citation

Kargar M, Mansouri A, Hadjibabaie M, Javadi M, Radfar M, Gholami K. Expert Opin. Drug Saf. 2014; 13(7): 875-891.

Copyright

(Copyright © 2014, Informa Healthcare)

DOI

10.1517/14740338.2014.925443

PMID

unavailable

Abstract

INTRODUCTION: Tuberculosis (TB) treatment, in particular therapy for multidrug-resistant TB (MDR-TB), is associated with toxicities and adverse drug reactions (ADRs).Areas covered: This paper reviews Iranian literature reporting ADRs which occurred during tuberculosis treatment. English language papers were sourced from PubMed, ScienceDirect, Wiley, Ovid and Proquest, with Google Scholar searched for Persian language articles. Reported ADRs, proportion of patients with ADRs, risk factors and determinants, as well as the characteristics of the studies were reviewed. 21 articles were included; about 60% of them were in English and three included patients with MDR-TB. The ratio of ADR per capita was 1.9 (in 6 studies) and 33.63% of patients developed an ADR (in 7 studies). Hepatitis (2.5-45.3%) was reported in nearly all of the studies. The mean time from initiation of medication to development of hepatitis ranged from 4.67 to 25.25 days (in 6 studies). Most cases of mortality were due to hepatotoxicity. Except for comorbidities and female gender, other risk factors such as HIV and length of hospitalization were only reported in one article.Expert opinion: The pattern of ADRs in Iranian articles was found to be similar to many other studies in the present review. We suggest that future studies resolve the confounding factors in this area that are mentioned in this review. © 2014 Informa UK, Ltd.

Language: en

Keywords

Humans; human; suicide; Iran; nephrotoxicity; abdominal pain; psychosis; hospitalization; treatment outcome; comorbidity; risk factor; review; Adverse drug reaction; Drug-Related Side Effects and Adverse Reactions; anorexia; vomiting; xerostomia; thrombocytopenia; headache; vertigo; constipation; tuberculosis; convulsion; diarrhea; nausea; epigastric pain; hepatitis; hyperuricemia; arthralgia; pruritus; tinnitus; liver toxicity; hypothyroidism; Tuberculosis; dysuria; tuberculostatic agent; hyperglycemia; drug fever; drug eruption; neuropathy; jaundice; Antitubercular Agents; eye toxicity; weakness; ototoxicity; hearing impairment; Medline; multidrug resistant tuberculosis; adverse drug reaction; Side effect; Drug induced hepatotoxicity; Multidrug-resistant tuberculosis