Citation

Morita S, Furukawa S, Wingenfeld L, Nishi K. Internet J. Forensic Med. Toxicol. 2013; 14(2).

Copyright

(Copyright © 2013, Anil Aggrawal)

DOI

unavailable

PMID

unavailable

Abstract

It has been described that the myocardium did not show any ischemic types of changes or other lesions in human hearts obtained from fatal carbon monoxide poisoning cases, although some report indicated the existence of pathological changes in the myocardium from carbon monoxide poisoning cases. We investigated the changes in myocardium obtained from several individuals who died in suicidal carbon monoxide poisoning, in house fire cases and in suicidal burning with kerosene using conventional staining. And we compared the results with those obtained from individual who died due to hypothermia. With conventional staining the cardiac cells from both group showed color-changing with HE (eosinphilic color changing) and Azan (orange color changing) stains, colliquative myocytolysis and contraction bands necrosis, respectively, however aggregated cardiac cells was find only in those from hypothermic death. The results obtained in this study and together with previous one indicate that death mechanism of carbon monoxide poisoning and hypothermic resemble to each other, that is, cardiac hypoxia is surely caused by disturbance of oxygen releasing from hemoglobin in hypothermia and by lacking of oxygen due to high affinity of carbon-monoxide to hemoglobin in CO poisoning, respectively.

Language: en

Keywords

human; suicide; female; male; hypothermia; aged; death; article; controlled study; clinical article; cell death; carbon monoxide; carbon monoxide intoxication; Carbon monoxide poisoning; carboxyhemoglobin; fire; kerosene; histopathology; heart muscle cell; heart muscle; cytolysis; Contraction band necrosis; Hypoxic myocardium