Citation

Raghu K, Rama Mohan P, Satish Kumar S, Srinivas M, Rajashekar ST, Subramanyam BV, Buchineni M. International Journal of Toxicological and Pharmacological Research 2013; 5(1): 26-29.

Copyright

(Copyright © 2013)

DOI

unavailable

PMID

unavailable

Abstract

Poisoning is one of the preferred means of suicide and Para-phenylenediamine (PPD), a common chromophoric ingredient in oxidative hair-dyes, is frequently used for this purpose. Crude estimates reveal that more than 500 patients received treatment for hair dye poisoning in our region. Reports have shown that increased free radical formation in PPD poisoning. N-acetylcysteine (NAC) is an antioxidant, both directly as a glutathione substitute and indirectly as a precursor for glutathione. In order to evaluate if the inclusion of NAC in the treatment of poisoning with PDD could be beneficial, a single center open label quasi experimental study was conducted at our hospital. We found that there was a significant reduction in the duration of ventilator support in the patients who received NAC (3.13±1.5days) as compared to patients who received standard care only (6.25±3.85 days) (p=0.01). However the duration of hospital stay was not statistically different. (p=0.56). Our results suggest that the inclusion of NAC treatment into standard care in hair dye poisoning may reduce duration of ICU stay and could thus be superior to standard care only.

Language: en

Keywords

adult; human; female; male; hemodialysis; intoxication; article; controlled study; clinical article; length of stay; stomach lavage; steroid; intensive care; drug efficacy; acute kidney failure; antihistaminic agent; artificial ventilation; acetylcysteine; alkalinization; add on therapy; respiratory distress; tracheostomy; open study; quasi experimental study; absence of side effects; hair dye; Glutathione; T wave inversion; N-Acetylcysteine; Acute kidney injury; N-acetetyltransferase; Para-phenylenediamine