Citation

Mood NE, Sabzghabaee AM, Ghodousi A, Yaraghi A, Massoumi G, Shemshaki HR. Pak. J. Med. Sci. Q. 2013; 29(1 Suppl): 403-408.

Copyright

(Copyright © 2013, Professional Medical Publications)

DOI

10.12669/pjms.291(Suppl).3543

PMID

unavailable

Abstract

OBJECTIVE: Acute paraquat (PQ) poisoning which is taken either to commit suicide or by mistake has become a social concern worldwide. The present study was conducted to determine the histo-pathological findings in deceased PQ poisoning patients and evaluate their relationship with age, gender, amounts of ingested PQ, time from ingestion to admission.

METHODology: Forty-two patients of PQ poisoning with positive urinary dithionate test were included in the study. Deceased patients underwent autopsy and their histo-pathological findings were examined.

RESULTS: The mean age of men and women were 29.06 ±10.6 and 16.66 ± 4.6 years respectively. Hepatocellular damage (60%), Tubular nephritis (60%) and pulmonary edema (50%) were the main pathological lesions. Logistic regression analyses identified the following significant predictors for poisoning-related liver lesions: age more than 20 years [odds ratio (OR), 13.75; 95% Confidence Interval (CI), 1.48 - 127.47], and ingested paraquat amounts more than 30 mg /kg (OR, 16; 95% CI, 1.32 - 194.62). There was also a significant correlation between liver lesions and age (Correlation Coefficient, 0.50; P value, 0.024); gender (Correlation Coefficient, 0.57; P value, 0.008); amount of ingested PQ (Correlation Coefficient, 0.55; P value, 0.012). There were no correlations between lung and kidney histopathological lesions with different variables.

CONCLUSION: Age, amount of ingested PQ, and gender are important parameters which may correlate with histopathological liver lesions in deceased PQ poisoning patients.

Language: en

Keywords

adult; human; age; Autopsy; Mortality; female; male; Poisoning; autopsy; Paraquat; risk assessment; paraquat; article; controlled study; clinical article; human tissue; liver cell damage; sensitivity and specificity; cross-sectional study; lung edema; liver injury; Toxicity; histopathology; fibrosis; kidney injury; receiver operating characteristic; interstitial nephritis; paraquat poisoning; toxicological parameters; cholestasis; diagnostic test accuracy study; Histopathology; amount of ingestion; lung lesion; urologic examination