Citation

Kato K, Yamada K, Akama F, Saito M, Kimito K, Kimoto K, Sato R, Ishida N, Ichimura A, Matsumoto H. Int. Med. J. 2012; 19(3): 208-210.

Copyright

(Copyright © 2012, Japan International Cultural Exchange Foundation)

DOI

unavailable

PMID

unavailable

Abstract

INTRODUCTION: Major depressive disorder is an important risk factor for suicide in adults. In Japan, few studies examining the efficacy and safety of pharmacotherapy in patients with this disorder hospitalized after suicide attempts have been reported. This study aimed to obtain preliminary data on the usefulness and safety of tandospirone combination therapy in patients with major depressive disorder, who were admitted to an emergency medical center in Japan following suicide attempts.

DESIGN: A retrospective study.

METHODS: We reviewed 56 consecutive patients with major depressive disorder who had been treated with antidepressants. The patients were divided into two groups: antidepressants monotherapy group and tandospirone combination therapy group. Hamilton Rating Scale of Depression-17 scores were used to evaluate the efficacy of tandospirone combination therapy.

RESULTS: Improvement rate in the tandospirone group was significantly higher than that in the antidepressants monotherapy group (P = 0.039). No serious adverse effects were recorded.

CONCLUSION: Tandospirone combined with an antidepressant may be effective and safe for treating major depressive disorder patients following suicide attempts. © 2012 Japan International Cultural Exchange Foundation & Japan Health Sciences University.

Language: en

Keywords

adult; human; Depression; Suicide; female; male; suicide attempt; major depression; treatment outcome; fatigue; article; major clinical study; retrospective study; hospital admission; fluvoxamine; mirtazapine; sertraline; xerostomia; headache; vertigo; drowsiness; constipation; drug safety; emergency health service; drug efficacy; diarrhea; nausea; tremor; Hamilton scale; side effect; monotherapy; tandospirone; Combination drug therapy; Emergency medical center; Tandospirone