Citation

Moreno Millán E, Rodríguez Muñoz R, Villegas del Ojo J. Rev. Toxicol. 2012; 29(2): 129-131.

Copyright

(Copyright © 2012, Asociación Española de Toxicología)

DOI

unavailable

PMID

unavailable

Abstract

The combination of several antihypertensives drugs for the treatment of hypertension is common and useful, though sometimes difficult to deal with a possible overdose or adverse effects. We report the case of a young patient who required intensive care for severe and prolonged hypotension with hypoperfusion and metabolic acidosis after the estimated ingestion of 1280 mg of candesartan and 500 mg of amlodipine for attempted suicide, assuming the first citation in the literature of an overdose by this therapy. We describe the clinical and laboratory status of the patient during the first 25 hours of evolution and the treatment applied, with special emphasis on the pathophysiology caused by the pharmacological characteristics of both drugs. © 2012, Asociacion Espanola de Toxicologia. All rights reserved.

Language: es

Keywords

Overdose; Hypotension; Amlodipine; Associations; Candesartan