Citation

Fausch K, Uehlinger DE, Jakob S, Pasch A. Clin. Kidney J. 2012; 5(2): 150-152.

Copyright

(Copyright © 2012, Oxford University Press)

DOI

10.1093/ckj/sfs020

PMID

unavailable

Abstract

Caffeine is the most widely consumed psychoactive substance worldwide. Intoxication causes central nervous system and haemodynamic complications, which have significant mortality rates. We report the case of a 39-year-old woman who ingested ∼0.5 mol (100 g) of pure caffeine, leading to a peak serum concentration of 2.95 mmol/L (574 mg/L). Three consecutive haemodialysis sessions caused serum caffeine reduction rates of 66, 46 and 45%, indicating that the unbound caffeine fraction is not dose linear in this high serum caffeine concentration range. Aggressive and repeated haemodialysis sessions may be of benefit in cases of severe caffeine intoxication. © 2012 The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

Language: en

Keywords

adult; human; female; resuscitation; case report; caffeine; hemodialysis; suicide attempt; intoxication; article; tachycardia; priority journal; activated carbon; tonic clonic seizure; ingestion; emergency health service; hypotension; acute kidney failure; amiodarone; blood level; heart rate; aspartate aminotransferase; creatine kinase; adrenalin; bicarbonate; defibrillation; magnesium; dobutamine; blood pressure; lactic acidosis; calcium; kidney function; crystalloid; heart ventricle extrasystole; endocarditis; intubation; treatment duration; continuous infusion; aspartate aminotransferase blood level; creatine kinase blood level; sinus rhythm; hemodiafiltration; stomach tube; distribution volume; caffeine poisoning; lung insufficiency; artificial kidney; chronic veno venous hemodiafiltration; haemodialysis