Citation

Philip J, Janaki R. Indian J. Psychiatry 2012; 54(2): 194-195.

Copyright

(Copyright © 2012, Medknow Publications)

DOI

10.4103/0019-5545.99543

PMID

unavailable

Abstract

Serotonin-reuptake inhibitors have come forth to become the mainstay of treatment in obsessive compulsive disorder (OCD), predominantly as a result of evidence from clinical psychopharmacological response studies. Comorbid psychiatric disorders frequent OCD patients, most often depression. Although selective serotonin reuptake inhibitors are effective in the treatment of both OCD and depressive disorder, all antidepressants are associated with treatment-emergent affective switch. We present a 48-year-old patient with OCD, on antidepressants, initially for OCD and later for depression as well. She switched to mania after 20 years of treatment, which responded to olanzapine and divalproex sodium.

Language: en

Keywords

adult; human; female; case report; insomnia; depression; Major depressive disorder; suicide attempt; fatigue; article; sexual behavior; clomipramine; fluoxetine; sexual intercourse; olanzapine; guilt; valproate semisodium; emotional stress; irritability; mania; agitation; obsessive compulsive disorder; psychosocial withdrawal; treatment response; contamination; drug dose increase; drug dose titration; pathological crying; drug dose escalation; selective serotonin reuptake inhibitors; treatment-emergent affective switch