Citation

Suzuki H, Inoue Y, Gen K. Ther. Adv. Psychopharmacol. 2012; 2(6): 227-234.

Copyright

(Copyright © 2012, SAGE Publishing)

DOI

10.1177/2045125312457585

PMID

unavailable

Abstract

We investigated the clinical efficacy and safety of switching to risperidone long-acting injection (RLAI) in older patients with schizophrenia receiving oral risperidone. The subjects were 48 inpatients who had been diagnosed with schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. Their clinical symptoms were assessed using the Positive and Negative Syndrome Scale and the Clinical Global Impression - Severity of Illness scale, and their safety was assessed using the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS), body weight, body mass index, and blood biochemistry tests. No significant differences in clinical symptom improvement efficacy were seen between the group switched to RLAI and the control group. The mean changes from baseline on the DIEPSS total score and prolactin level were significantly greater in the older group switched to RLAI than in the control group. Furthermore, in older patients, RLAI allowed the dosage of the concomitant medication to be significantly reduced compared with the control group. The results of this study suggest that switching older patients from oral risperidone to RLAI may result in superior efficacy and safety, and may also make it possible to reduce the dosage of the concomitant medication. © 2012, SAGE Publications. All rights reserved.

Language: en

Keywords

adult; human; female; male; safety; schizophrenia; suicide attempt; article; controlled study; clinical article; priority journal; controlled clinical trial; diazepam; psychopharmacotherapy; drug safety; mental patient; hospital patient; drug efficacy; risperidone; tardive dyskinesia; negative syndrome; Efficacy; biperiden; positive syndrome; malignant neoplastic disease; drug response; long acting drug; magnesium oxide; drug dose increase; injection site erythema; injection site pain; Clinical Global Impression scale; Positive and Negative Syndrome Scale; injection site swelling; injection site induration; older patients with schizophrenia; risperidone long-acting injection; sennoside