Citation

Radenkova-Saeva J. Acta Med. Bulg. 2011; 38(2): 59-61.

Copyright

(Copyright © 2011, Medical Information Center)

DOI

unavailable

PMID

unavailable

Abstract

Baclofen is a lipophilic analogue of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in central nervous system. It is a muscle relaxant used in persons with neuromuscular disorders to control spasticity. Intentional or accidental overdose of this drug can cause profound central nervous system depression, including coma, seizures, respiratory depression, and cardiovascular effects such as bradycardia, hypotonia. A case of baclofen self-poisoning was presented in a 21-year-old woman, hospitalized in the Toxicology Clinic, MHATEM "Pirogov" with coma and respiratory depression. Primary importance in the treatment and management of such ingestions should focus on airway and respiratory support.

Language: en

Keywords

adult; human; female; Seizures; case report; suicide attempt; article; somnolence; self poisoning; stomach lavage; coma; thioridazine; activated carbon; seizure; artificial ventilation; diuresis; respiratory failure; Self-poisoning; respiration depression; Coma; Baclofen; baclofen; muscle hypotonia; hyporeflexia; dry skin; piracetam; lisinopril; endotracheal tube; Respiratory depression