Citation

Ávila DS, Palma AS, Colle D, Scolari R, Manarin F, Da Silveira AF, Nogueira CW, Rocha JBT, Soares FAA. Eur. J. Pharmacol. 2011; 661(1-3): 92-101.

Copyright

(Copyright © 2011, Elsevier Publishing)

DOI

10.1016/j.ejphar.2011.04.031

PMID

unavailable

Abstract

Acetaminophen (APAP) hepatotoxicity has been related with several cases of cirrhosis, hepatitis and suicides attempts. Notably, oxidative stress plays a central role in the hepatic damage caused by APAP and antioxidants have been tested as alternative treatment against APAP toxicity. In the present study, we observed the hepatoprotector activity of the diethyl-2-phenyl-2-tellurophenyl vinylphosphonate (DPTVP), an organotellurium compound with low toxicity and high antioxidant potential. When the dose of 200 mg/kg of APAP was used, we observed that all used doses of DPTVP were able to restore the -SH levels that were depleted by APAP. Furthermore, the increase in thiobarbituric acid reactive substances levels and in the seric alanine aminotransferase (ALT) activity and the histopathological alterations caused by APAP were restored to control levels by DPTVP (30, 50 and 100 μmol/kg). On the other hand, when the 300 mg/kg dose of APAP was used, DPTVP restored the non-proteic -SH levels and repaired the normal liver morphology of the intoxicated mice only at 50 μmol/kg. Our in vitro results point out to a scavenging activity of DPTVP against several reactive species, action that is attributed to its chemical structure. Taken together, our results demonstrate that the pharmacological action of DPTVP as a hepatoprotector is probably due to its scavenging activity related to its chemical structure. © 2011 Elsevier B.V. All rights reserved.

Language: en

Keywords

male; Acetaminophen; glutathione; oxidative stress; article; controlled study; unclassified drug; priority journal; drug structure; paracetamol; nonhuman; enzyme activity; mouse; drug effect; animal experiment; alanine aminotransferase; liver toxicity; liver injury; animal model; Oxidative stress; in vitro study; animal tissue; nitric oxide; hydrogen peroxide; liver protection; antioxidant activity; liver histology; -SH levels; 1,1 diphenyl 2 picrylhydrazyl; diethyl 2 phenyl 2 tellurophenyl vinylphosphonate; Hepatoprotection; Histopathological analysis; hydroxyl radical; liver protective agent; liver structure; Tellurium; thiobarbituric acid reactive substance