Citation

Kumari R, Kaundal M, Ahmad Z, Ashwalayan VD. International Journal of Pharmaceutical Sciences Review and Research 2011; 10(1): 217-224.

Copyright

(Copyright © 2011)

DOI

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PMID

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Abstract

Schizophrenia is a debilitating, hereditary, disorder of the brain, resulting from abnormalities that arises early in life and disrupt normal development of the brain and has a lifetime risk of 1% and affects at all age groups, approximately 10% die from suicide. Although antipsychotic drugs are the mainstay of treatment of schizophrenia, but they are associated with serious adverse effects such as tardive dyskinesia, oxidative stress, EPS. In addition, about 20% of people do not respond adequately to the treatment. Growing evidences supporting the dysregulation of antioxidant defense mechanism and a parallel increase in oxidantive load has been reported by several studies in schizophrenia. Although oxidative stress was produced by long term use of conventional antipsychotic medication, Ayurvedic herbal medicines and some dietary supplements score positively on this aspect, since they can be used long-term without any serious side effects and also possess antioxidant potential. Several herbal and dietary combinations are now available which can be used independently in patients with mild to moderate symptoms of schizophrenia. For Schizophrenic patients with severe symptoms, the Ayurvedic medicines and dietary supplements can be added to a modern medicine as adjuvant therapy, so that the therapeutic effect is optimized, without increasing the side-effect load.

Language: en

Keywords

human; herbal medicine; Schizophrenia; depression; schizophrenia; drug use; oxidative stress; article; mental disease; neuroleptic agent; fluoxetine; sedation; xerostomia; headache; anxiety disorder; sleep disorder; vitamin; nonhuman; drug safety; drug potentiation; drug efficacy; olanzapine; tardive dyskinesia; nausea; tremor; side effect; amnesia; brain hemorrhage; antioxidant; gastrointestinal disease; hypnotic sedative agent; drug contraindication; 4 aminobutyric acid; ataxia; tranquilizing activity; Oxidative stress; melatonin; drug hypersensitivity; skin allergy; unspecified side effect; Antioxidants; Hypericum perforatum extract; memory disorder; herbaceous agent; ascorbic acid; alpha tocopherol; dopaminergic activity; skin disease; mydriasis; Glycine; blurred vision; stomach disease; diet supplementation; antiinflammatory activity; valerian; oxazepam; skin discoloration; glycine; amine oxidase (flavin containing); vitamin supplementation; Dietary supplements; Ginkgo biloba extract; neurotransmitter release; kawain; GABAergic transmission; antidepressant activity; 5,8,11,14,17 icosapentaenoic acid; contact allergy; Crocus sativus extract; ginseng; ginsenoside; Herbal drug; jujube; kava; laziness; Rhodiola rosea extract; sarcosine; thioctic acid; Withania somnifera extract